期刊
BIOSCIENCE REPORTS
卷 34, 期 -, 页码 429-440出版社
PORTLAND PRESS LTD
DOI: 10.1042/BSR20140095
关键词
Cyld; Drosophila; IKK; NF-kappa B; hypoxia; immune response
资金
- Portuguese Science Foundation
- Graduate Programme in Areas of Basic and Applied Biology (GABBA)
- Medical Research Council (MRC) [MR/K018531/1, G0901020]
- CR-UK Senior Research Fellowship [C99667/A12918]
- Wellcome Trust Strategic Award [097945/B/11/Z]
- MRC [MR/K018531/1, G0501679, G0901020] Funding Source: UKRI
- Cancer Research UK [12918] Funding Source: researchfish
- Medical Research Council [MR/K018531/1, G0901020, G0501679] Funding Source: researchfish
Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival. In mammalian cells, hypoxia not only activates the HIF (hypoxia-inducible factor) family, but also additional transcription factors such as NF-kappa B (nuclear factor kappa B). Here we show that hypoxia activates the IKK-NF-kappa B [I kappa B (inhibitor of nuclear factor kappa B)-NF-kappa B] pathway and the immune response in Drosophila melanogaster. We show that NF-kappa B activation is required for organism survival in hypoxia. Finally, we identify a role for the tumour suppressor Cyld, as a negative regulator of NF-kappa B in response to hypoxia in Drosophila. The results indicate that hypoxia activation of the IKK-NF-kappa B pathway and the immune response is an important and evolutionary conserved response.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据