期刊
CURRENT OPINION IN BEHAVIORAL SCIENCES
卷 23, 期 -, 页码 42-48出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cobeha.2018.03.007
关键词
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资金
- NIH [MH109471, DA035008, DA41808, DA013680]
- NSF IOS [1256799]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH109471] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA041808, R01DA013680, R56DA013680, R01DA035008] Funding Source: NIH RePORTER
The striatal brain regions, including the caudate-putamen, nucleus accumbens core, and nucleus accumbens shell, mediate critical behavioral functions. These functions include motivated behavior, learning, and sensorimotor function in both pathological and normal contexts. The phenotype and/or incidence of all of these behaviors differ by sex and/or are sensitive to gonadal hormones such as 17 beta-estradiol. Here we present a brief review of recent literature regarding sex differences and effects of 17 beta-estradiol on behavioral and neural function across striatal regions. We emphasize recent findings in striatal-relevant behaviors and disorders, striatal neuron dendritic spine density, and striatal neuron electrophysiology. These recent advances collectively offer insight into the effects of sex and estrogen on striatal function, especially at the level of individual neurons.
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