期刊
BIOSCIENCE REPORTS
卷 33, 期 -, 页码 711-719出版社
PORTLAND PRESS LTD
DOI: 10.1042/BSR20130046
关键词
beige fat; browning; peroxisome-proliferator-activated receptor gamma (PPAR gamma); peroxisome-proliferator-activated receptor gamma coactivator 1-alpha (PGC-1 alpha); PR domain containing 16 (PRDM16); white adipocytes
资金
- NRF [NRF-2011NRF-NRFF 001-025]
Adipose tissue has a central role in the regulation of energy balance and homoeostasis. There are two main types of adipose tissue: WAT (white adipose tissue) and BAT (brown adipose tissue). WAT from certain depots, in response to appropriate stimuli, can undergo a process known as browning where it takes on characteristics of BAT, notably the induction of UCP1 (uncoupling protein 1) expression and the presence of multilocular lipid droplets and multiple mitochondria. How browning is regulated is an intense topic of investigation as it has the potential to tilt the energy balance from storage to expenditure, a strategy that holds promise to combat the growing epidemic of obesity and metabolic syndrome. This review focuses on the transcriptional regulators as well as various proteins and secreted mediators that have been shown to play a role in browning. Emphasis is on describing how many of these factors exert their effects by regulating the three main transcriptional regulators of classical BAT development, namely PRDM16 (PR domain containing 16), PPAR gamma (peroxisome proliferator-activated receptor gamma) and PGC-1 alpha (peroxisome proliferator-activated receptor gamma coactivator 1 alpha), which have been shown to be the key nodes in the regulation of inducible brown fat.
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