期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 79, 期 1, 页码 11-15出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09168451.2014.955455
关键词
indole diterpene; total synthesis; antimitotic; kinesin spindle protein; terpendole
The first synthesis of the racemate of terpendole E, a specific inhibitor of the mitotic kinesin Eg5, has been achieved from a known tricyclic dihydroxy ketone by a 13-step sequence that involves diastereoselective installation of its C3 quaternary stereocenter via a cyclopropyl ketone intermediate and Pd-mediated two-step construction of the indole ring moiety as the key transformations.
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