期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 78, 期 9, 页码 1592-1602出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09168451.2014.925782
关键词
fructo-oligosaccharides; immunoglobulin A; mucin; cecum; rats
类别
资金
- Ministry of Education, Science, Sports and Culture of Japan
- Grants-in-Aid for Scientific Research [25660101] Funding Source: KAKEN
We examined the effects of fructo-oligosaccharides (FOS) on IgA and mucin secretion in the rat cecum after different ingestion periods. Rats were fed a control diet or a diet containing FOS for 1, 2, 4, and 8 wk. FOS ingestion greatly increased IgA and mucin concentrations at 1 and 2 wk, but the effects were disappeared or attenuated at 4 and 8 wk. After 1 wk, FOS induced higher lactobacilli and lactate concentrations and lower cecal pH in the cecum, but the alterations were moderated with the prolonged ingestion accompanying with increasing short-chain fatty acid concentrations. At 1 and 2 wk, FOS increased IgA plasma cells and polymeric immunoglobulin receptor expression in the cecal mucosa and strongly depressed fecal mucinase activities related to the lower cecal pH. These findings may explain the FOS-induced early elevation of IgA and mucin. Clearly, FOS effects on IgA and mucin secretion considerably differ depending on the ingestion period.
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