期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 79, 期 2, 页码 247-252出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09168451.2014.972324
关键词
fibroblast cells; promoter activity; curcumin; fibrillin-1; elastin
类别
资金
- Ministry of Science and Technology of the Republic of China (Taiwan) [NSC102-2313-B-126-001-MY3]
Curcumin is the major component of the yellow extract derived from the rhizome of the Curcuma longa, which is also a main bioactive polyphenol and has been generally used as a spice, food additive, and herbal medicine. In this presented study, we found that curcumin can enhance the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells via increasing ELN and FBN1 promoters' activities. With 2 mu M curcumin treatment, the enhanced tropoelastin and fibrillin-1 protein amounts in Detroit 551 cells were approximately 134 and 130% of control, respectively. Therefore, our results demonstrated that curcumin may be used as a functional compound and applied to drugs, foods, and cosmetics in the future.
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