期刊
CURRENT OPINION IN BEHAVIORAL SCIENCES
卷 20, 期 -, 页码 67-74出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cobeha.2017.11.005
关键词
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资金
- National Institutes of Health [DA035443, MH106972]
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH106972] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA035443] Funding Source: NIH RePORTER
Habits are an essential and pervasive component of our daily lives that allow us to efficiently perform routine tasks. But their disruption contributes to the symptoms that underlie many psychiatric diseases. Emerging data are revealing the cellular and molecular mechanisms of habit formation in the dorsal striatum. New data suggest that in both the dorsolateral and dorsomedial striatum histone deacetylase (HDAC) activity acts as a critical negative regulator of the transcriptional processes underlying habit formation. In this review, we discuss this recent work and draw conclusions relevant to the treatment of diseases marked by maladaptive habits.
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