期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 77, 期 8, 页码 1766-1768出版社
OXFORD UNIV PRESS
DOI: 10.1271/bbb.120979
关键词
aromatic amino acid; 4-hydroxyphenyllactic acid; indole-3-lactic acid; interleukin-6 (IL-6); keratinocyte
类别
资金
- National Agriculture and Food Research Organization (NARO) of Japan
The anti-inflammatory effects of lactic acid derivatives were investigated on ultraviolet B (UVB)-irradiated HaCaT human keratinocytes. A pretreatment with indole-3-lactic acid (ILA) and 4-hydroxyphenyllactic acid (HPLA) inhibited the UVB-induced production of interlekin-6 (IL-6). The inhibitory effect of L-HPLA was equivalent to that of a corresponding racemic mixture (DL-HPLA), suggesting that optical isomerism did not affect the anti-inflammatory activity of HPLA.
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