Orally and Topically Administered Sparassis crispa (Hanabiratake) Improved Healing of Skin Wounds in Mice with Streptozotocin-Induced Diabetes

Sparassis crispa (SC) contains significant concentrations of beta-glucan, which can accelerate wound healing, but the dose dependence for oral administration and the effects of topical administration are unknown. In streptozotocin-induced diabetic mice, dietary SC promoted dose-dependent effective wound healing. Similar wound healing activity was observed when purified SC beta-glucan was topically applied to wounds of diabetic mice.