期刊
METALLOMICS
卷 10, 期 12, 页码 1723-1727出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8mt00274f
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资金
- Centre for Preclinical Research and Technology (CePT)
- European Regional Development Fund and Innovative Economy, The National Cohesion Strategy of Poland
- Preludium grant [2016/21/N/NZ1/02785]
- Opus grant [2016/23/B/ST5/02253]
- National Science Centre of Poland
- Frontier Research in Chemistry Foundation [CSC-PFA-17]
- Polish Science - Polish Ministry of Science and Higher Education [1632/MOB/V/2017/0]
- Research Corporation for Science Advancement Cottrell Scholar Award [23666]
- DOE Office of Biological and Environmental Research
- National Institutes of Health, National Center for Research Resources, Biomedical Technology Program [P41RR001209]
Human cells acquire copper primarily via the copper transporter 1 protein, hCtr1. We demonstrate that at extracellular pH 7.4 Cu-II is bound to the model peptide hCtr1(1-14)via an ATCUN motif and such complexes are strong enough to collect Cu-II from albumin, supporting the potential physiological role of Cu-II binding to hCtr1.
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