期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 76, 期 2, 页码 381-383出版社
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.110665
关键词
benzyl isothiocyanate; alpha-tocopherol; apoptosis; caspase-3; HL-60 cells
类别
资金
- Grants-in-Aid for Scientific Research [21680052, 23650486, 24680075, 22580129] Funding Source: KAKEN
Pre-treatment with alpha-tocopherol (alpha-Toc) potentiated cytotoxicity induction by benzyl isothiocyanate (BITC). Biochemical events related to apoptosis, such as DNA ladder formation and caspase-3 activation, were also enhanced by alpha-Toc. These results suggest a significant role of the caspase-3 pathway in apoptosis induction regulated by alpha-Toc in combination.
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