期刊
NATURE REVIEWS IMMUNOLOGY
卷 18, 期 1, 页码 35-45出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri.2017.76
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资金
- National Institutes of Health Director's New Innovator Award Program [DP2-HG-009623]
Advances in single-cell RNA sequencing (scRNA-seq) have allowed for comprehensive analysis of the immune system. In this Review, we briefly describe the available scRNA-seq technologies together with their corresponding strengths and weaknesses. We discuss in depth how scRNA-seq can be used to deconvolve immune system heterogeneity by identifying novel distinct immune cell subsets in health and disease, characterizing stochastic heterogeneity within a cell population and building developmental 'trajectories' for immune cells. Finally, we discuss future directions of the field and present integrated approaches to complement molecular information from a single cell with studies of the environment, epigenetic state and cell lineage.
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