期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 76, 期 10, 页码 1938-1942出版社
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.120427
关键词
chronological lifespan; yeast; Ecl1; mitochondria; respiration
类别
资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Asahi Glass Foundation
- Nagase Science and Technology Foundation
Ecl1, a product of the YGR146C gene in Saccharomyces cerevisiae, was identified as a factor involved in chronological lifespan. In this study we found evidence that the function of Ecl1 in the extension of chronological lifespan is dependent on mitochondrial function. The respiratory activity of cells increased when Ecl1 was overexpressed or cells were grown under calorie restriction, but there was no additive effect of calorie restriction and Ecl1 overexpression on increases in respiratory activity or on the extension of chronological lifespan. Based on these results, we propose that overexpression of Ecl1 has same effect as caloric restriction and that its function also depends on mitochondria, just like caloric restriction.
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