期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 75, 期 9, 页码 1668-1676出版社
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.110163
关键词
alcohol; catechin; caffeine; oxidative stress; lipogenesis
类别
资金
- equipment service of the third core laboratory of Department of Medical Research at NTUH
- National Science Council of the Republic of China [NSC96-2320-B-002-007, NSC96-2221-E-002-256-MY3]
- [NTUH98-S1141]
- [NTUH98-M1216]
We determined the effects of a green tea extract with 36% alcohol on the blood alcohol content, oxidative stress, lipogenesis, inflammation and liver function of female Wistar rats. Tea alcohol significantly decreased the O-2(-), H2O2 and HOCl amounts via catechins and not caffeine. Thirty days of alcohol gavage improved the level of reactive oxygen species (ROS) in the liver, bile and blood, increased the 4-hydroxynonenal-protein adducts, Kupffer cell infiltration and lipid accumulation in the liver, and elevated the plasma alanine aminotransferase level. A western blot analysis showed reduced expression of the oxidative enzymes (CYP2E1 and NADPH oxidase p47phox protein) and lipogenic enzymes (SREBP-1c and fatty acid synthase) in the alcohol-treated liver. Tea alcohol significantly attenuated these elevated parameters. We conclude that the green tea extract in alcohol efficiently reduced the amounts of O-2(-), H2O2 and HOCl primarily due to the catechin content, and not caffeine. The developed tea liquor attenuated alcohol-induced oxidative injury and lipogenesis in the liver by the synergetic action of catechins and caffeine.
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