期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 75, 期 8, 页码 1413-1417出版社
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.110087
关键词
Bacillus subtilis; isoprenoid; post-translational modification; quorum sensing; tryptophan
类别
资金
- Grants-in-Aid for Scientific Research [23658098] Funding Source: KAKEN
Bacillus subtilis and related bacilli produce a post-translationally modified oligopeptide, ComX pheromone, that stimulates natural genetic competence controlled by quorum sensing. The ComX pheromones are formed by geranylation or farnesylation on a tryptophan residue at the 3 position of its indole ring. This results in the formation of a tricyclic structure including, a newly formed five-membered ring, similar to proline. Isoprenylation of ComX to form ComX pheromones is essential for pheromonal activity, and is functionally more crucial than its amino acid sequence. The ComX pheromone is the first example of isoprenoidal modifiations of tryptophan residues in living organisms and post-translational isoprenylation of any amino acid in prokaryotes. Because the presence of geranylated compounds is unusual in primary and secondary metabolites outside the plant kingdom, post-translational geranylation in bacilli is unprecedented in nature.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据