期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 74, 期 10, 页码 2096-2099出版社
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.100193
关键词
proline-hydroxyproline (Pro-Hyp); hyaluronic acid; collagen hydrolysates; osteoarthritis; proteoglycan
类别
资金
- Grants-in-Aid for Scientific Research [22590498] Funding Source: KAKEN
Proline-hydroxyproline (Pro-Hyp) stimulated hyaluronic acid production in cultured synovium cells. It was detected in guinea pig blood after oral ingestion of collagen hydrolysates. Oral administration of collagen hydrolysates increased the amount of proteoglycans in the epiphyses. It also reduced the morphological changes associated with osteoarthritic cartilage destruction of the knee joint. The results suggest that collagen hydrolysates have therapeutic potential for treatment of osteoarthritis.
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