期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 74, 期 11, 页码 2299-2306出版社
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.100524
关键词
silymarin; Alzheimer's disease; amyloid beta; mouse model
类别
资金
- Program for the Promotion of Basic Research Activities for Innovative Biosciences
- Ministry of Education, Culture, Sports, Science, and Technology of the Japanese Government
- [20390085]
- [20500641]
- [18208011]
- [21248015]
- Grants-in-Aid for Scientific Research [21248015] Funding Source: KAKEN
Alzheimer's disease (AD) is characterized by progressive cognitive impairment and the formation of senile plaques. Silymarin, an extract of milk thistle, has long been used as a medicinal herb for liver diseases. Here we report marked suppression of amyloid beta-protein (A beta) fibril formation and neurotoxicity in PC12 cells after silymarin treatment in vitro. In vivo studies had indicated a significant reduction in brain A beta deposition and improvement in behavioral abnormalities in amyloid precursor protein (APP) transgenic mice that had been preventively treated with a powdered diet containing 0.1% silymarin for 6 months. The silymarin-treated APP mice also showed less anxiety than the vehicle-treated APP mice. These behavioral changes were associated with a decline in A beta oligomer production induced by silymarin intake. These results suggest that silymarin is a promising agent for the prevention of AD.
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