期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 73, 期 4, 页码 870-878出版社
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.80795
关键词
transcriptional cascade; EvgS/EvgA; YdeO; GadE; acid resistance
类别
资金
- Japan Society for the Promotion of Science (JSPS) [20248012]
- Ministry of Education. Culture, Sports, Science, and Technology. Japan
Using an EvgS-active mutant (evgSI) in combination with gene deletions, we clarified the molecular mechanism of the transcriptional cascade of acid resistance and multidrug resistance genes initiated by the EvgS/EvgA two-component system in Escherichia coli, followed by sequential induction of the transcriptional regulators, YdeO and GadE. Overexpression of EvgA, the response regulator of the EvgS/EvgA system, is known to induce the expression of a number of acid resistance and multidrug resistance genes, in which the EvgA-YdeO-GadE circuit is involved, but the role of the sensor EvgS in this circuit has remained unsolved. Our results suggest that the transcriptional cascade initiated by the EvgS/EvgA system in fact functions for acid and drug resistance in E. coli.
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