期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 73, 期 8, 页码 1905-1907出版社
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.90265
关键词
zerumbone; anti-inflammation; detoxification; RAW264.7; affinity chromatography
类别
资金
- Ministry of Health, Labor, and Welfare of Japan
Zerumbone (ZER), a sesquiterpene in Zingiber zerumbet Smith, has been implicated as a promising chemopreventive agent. Here we found that ZER suppressed expression of pro-inflammatory genes (COX-2 and iNOS) and induced detoxification genes (GSTP1 and NQO1) in RAW264.7 macrophages. Using the ZER-bound Sepharose gel, it appeared ZER was covalently bound to proteins, Keap1 and HuR, that play key roles in these molecular mechanisms.
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