期刊
MOVEMENT DISORDERS CLINICAL PRACTICE
卷 5, 期 5, 页码 538-541出版社
WILEY
DOI: 10.1002/mdc3.12658
关键词
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资金
- National Key Research and Development Program of China [2016YFC0105900]
- National Natural Science Foundation of China [81527901]
Introduction Deep brain stimulation (DBS) with high frequency (HFS) is a well-established therapy for Parkinson's disease (PD); however, low frequency DBS (LFS) may control axial symptoms including freezing of gait (FOG). We conducted a pilot safety and feasibility study to examine if a novel DBS paradigm of variable frequency stimulation (VFS) that combined HFS and LFS would capture a broader set of motor symptoms. MethodsResultsFour PD patients with bilateral STN DBS and FOG were enrolled. A UPDRS III and 10m timed up and go (TUG) task were performed off medications-off DBS and then one hour after HFS and one hour after VFS programming. The UPDRS III motor score improved by additional 14% during VFS setting when compared to HFS. VFS also increased gait speed (mean change 45%) and reduced the number of freezing episodes (mean change 58%). ConclusionsVFS improves UPDRS and FOG in PD when compared to HFS.Copyright (c) 2018 International Parkinson and Movement Disorder Society
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