期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 72, 期 11, 页码 2992-2997出版社
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.80562
关键词
Cortisium simplex; cortistatin A; synthesis; HUVEC; angiogenesis
类别
资金
- Japan Society for the Promotion of Science [19580120]
Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.
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