期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 72, 期 8, 页码 2214-2218出版社
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.80229
关键词
curcumin analogs; thioredoxin; thioredoxin reductase inhibitors
类别
资金
- NSFC/RGC Joint Research Scheme [30731160006]
- N-PolyU [508/06]
- NSFC Grant [20772159]
- Hong Kong Polytechnic University [APD96]
Curcumin analogs were first investigated for their inhibitory effects on thioredoxin reductase (TrxR). Most of them were more potent TrxR inhibitors than natural curcumin. The structure-activity relationship was summarized, and the curcumin analog was found to inhibit TrxR irreversibly in a time-dependent manner. The action was caused by covalent modification of the redox-active residues Cys(497) and Sec(498) in TrxR.
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