Bioactive inorganic/organic nanocomposites for wound healing

Regeneration of skin tissues with anatomic and functional integrity after injury remains a great challenge due to the complexity of wound healing. In the past decade, numerous efforts have been made to construct engineered nanocomposites with combination of organic polymeric networks and inorganic bioactive nanoparticles for facilitating the healing process. In this review, we aim to critically summarize the state-of-art progress on the bioactive inorganic/organic nanocomposites for wound healing. Followed by a brief discussion on the design principle of inorganic/organic nanocomposites, we describe two typical preparation methods with comments on their advantages and drawbacks in wound healing applications. The current applications of inorganic/organic nanocomposites with particular emphasis on their bioactive characteristics are also presented. Finally, concluding remarks and personal insights on the challenges and outlooks are addressed.(C) 2018 Elsevier Ltd. All rights reserved.