期刊
BIOSCIENCE
卷 58, 期 11, 页码 1061-1067出版社
AMER INST BIOLOGICAL SCI
DOI: 10.1641/B581109
关键词
endocrine-disrupting chemicals; environmental estrogens; organotins; adipogenesis; nuclear receptors
类别
资金
- Japanese Ministries of Education, Culture, Sports, Science and Technology
- Japanese Ministries of Environment
- Japanese Ministries of Health, Labour and Welfare
- Japanese Chemical Industry Association
Several nuclear receptors have recently been identified as mediators of endocrine disruption as well as steroid hormone receptors. The ubiquitous environmental contaminant tributyltin chloride (TBT) is a ligand for retinoid X receptor (RXR) in rock shell at the nanomolar level, and it acts as a ligand for both the RXR and the peroxisome proliferator-activated receptor gamma in the frog Xenopus laevis and in humans. TBT which induces imposex in marine snails and promotes adipogenesis in X. laevis and in mice, is an example of an environmental endocrine disrupter that promotes adverse effects, from the snail to mammals, through common signaling. In addition, juvenile hormone agonists used as pesticides showed endocrine-disruptive effects on parthenogenic Daphnia magna, lowering rates of reproduction, and inducing 100% male offspring. In this article, we focus on commonality in signaling through nuclear receptors and newly endocrine disruption in D.magna.
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