期刊
BIOMEDICINES
卷 6, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines6020066
关键词
noncanonical NF-kappa B; cancer; cellular signaling; inflammation; tumor initiating cells; NIK; RelB; p52
资金
- National Institutes of Health (NIH)
- NATIONAL CANCER INSTITUTE [P30CA016086] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007092] Funding Source: NIH RePORTER
The NF-kappa B pathway is a critical regulator of immune responses and is often dysregulated in cancer. Two NF-kappa B pathways have been described to mediate these responses, the canonical and the noncanonical. While understudied compared to the canonical NF-kappa B pathway, noncanonical NF-kappa B and its components have been shown to have effects, usually protumorigenic, in many different cancer types. Here, we review noncanonical NF-kappa B pathways and discuss its important roles in promoting cancer. We also discuss alternative NF-kappa B-independent functions of some the components of noncanonical NF-kappa B signaling. Finally, we discuss important crosstalk between canonical and noncanonical signaling, which blurs the two pathways, indicating that understanding the full picture of NF-kappa B regulation is critical to deciphering how this broad pathway promotes oncogenesis.
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