期刊
MOLECULES AND CELLS
卷 41, 期 3, 页码 168-178出版社
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
DOI: 10.14348/molcells.2018.0008
关键词
E2 ubiquitin-conjugating enzyme; E3 ubiquitin ligase; pathogenesis; ubiquitination; UBE2O
资金
- Cancer Prevention Research Institute of Texas [RP150084]
- Department of Defense [W81XWH-15-1-0662]
- National Institutes of Health [CA196740]
- NRF of Korea - Ministry of Science, ICT & Future Planning [NRF-2016K1A4A3914725]
- Korea Health Technology R&D Project through KHIDI - Ministry of Health Welfare [HI15C2679]
- NATIONAL CANCER INSTITUTE [R01CA196740] Funding Source: NIH RePORTER
Intracellular communication via ubiquitin (Ub) signaling impacts all aspects of cell biology and regulates pathways critical to human development and viability; therefore aberrations or defects in Ub signaling can contribute to the pathogenesis of human diseases. Ubiquitination consists of the addition of Ub to a substrate protein via coordinated action of E1-activating, E2-conjugating and E3-ligating enzymes. Approximately 40 E2s have been identified in humans, and most are thought to be involved in Ub transfer; although little information is available regarding the majority of them, emerging evidence has highlighted their importance to human health and disease. In this review, we focus on recent insights into the pathogenetic roles of E2s (particularly the ubiquitin-conjugating enzyme E2O [UBE2O]) in debilitating diseases and cancer, and discuss the tantalizing prospect that E2s may someday serve as potential therapeutic targets for human diseases.
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