期刊
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
卷 2, 期 2, 页码 228-239出版社
WILEY
DOI: 10.1002/rth2.12092
关键词
bleeding; glycoprotein VI; inflammation; platelets; vascular integrity
资金
- Force Hemato
- La Fondation Arc [PJA 20151203107]
- La Fondation pour la Recherche Medicale [FRM ARF20140129191]
- DHU Fire [012]
- INCA
- Marie Curie Action [708973]
Glycoprotein VI (GPVI), the main platelet receptor for collagen, has been shown to play a central role in various models of thrombosis, and to be a minor actor of hemostasis at sites of trauma. These observations have made of GPVI a novel target for antithrombotic therapy, as its inhibition would ideally combine efficacy with safety. Nevertheless, recent studies have indicated that GPVI could play an important role in preventing bleeding caused by neutrophils in the inflamed skin and lungs. Remarkably, there is evidence that the GPVI-dependent hemostatic function of platelets at the acute phase of inflammation in these organs does not involve aggregation. From a therapeutic perspective, the vasculoprotective action of GPVI in inflammation suggests that blocking of GPVI might bear some risks of bleeding at sites of neutrophil infiltration. In this review, we summarize recent findings on GPVI functions in inflammation and discuss their possible clinical implications and applications.
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