期刊
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
卷 62, 期 11-12, 页码 837-846出版社
UNIV BASQUE COUNTRY UPV-EHU PRESS
DOI: 10.1387/ijdb.180192sz
关键词
Hox; heart development; congenital heart disease; cardiovascular system
资金
- AFM-Telethon Strategic Project award
- la Fondation Lefoulon-Delalande
Hox genes are highly conserved transcription factors with critical functions during development, in particular for patterning the antero-posterior axis of the embryo. Their action is very often associated with cofactors including the TALE family transcription factors. From Drosophila to vertebrates, Hox genes have been shown to have a major role in heart development. In this review, we focus on the increasing evidence implicating the anterior Hoxgenes and the Tale family members during heart development both in the cardiac mesoderm and in neural crest cells. Congenital heart defects are the leading cause of death in the first year of life and a better understanding of the role of Hox and Tale factors is highly relevant to human pathologies and will provide novel mechanistic insights into the underlying defects.
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