期刊
MICROBIOLOGY SPECTRUM
卷 6, 期 5, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/microbiolspec.RWR-0032-2018
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资金
- Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIH [R01 GM092830]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM092830] Funding Source: NIH RePORTER
Bacteria are known to use RNA, either as mRNAs encoding proteins or as noncoding small RNAs (sRNAs), to regulate numerous biological processes. However, a few sRNAs have two functions: they act as base-pairing RNAs and encode a small protein with additional regulatory functions. Thus, these so called dual-function sRNAs can serve as both a riboregulator and an mRNA. In some cases, these two functions can act independently within the same pathway, while in other cases, the base-pairing function and protein function act in different pathways. Here, we discuss the five known dual-function sRNAs-SgrS from enteric species, RNAIII and Psm-mec from Staphylococcus aureus, Pel RNA from Streptococcus pyogenes, and SR1 from Bacillus subtilis-and review their mechanisms of action and roles in regulating diverse biological processes. We also discuss the prospect of finding additional dual-function sRNAs and future challenges in studying the overlap and competition between the functions.
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