期刊
BIORESOURCE TECHNOLOGY
卷 135, 期 -, 页码 544-554出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biortech.2012.11.047
关键词
Metabolic engineering; Biorefinery; Corynebacterium glutamicum; Escherichia coli; Saccharomyces cerevisiae
Bio-based production promises a sustainable route to myriads of chemicals, materials and fuels. With regard to eco-efficiency, its future success strongly depends on a next level of bio-processes using raw materials beyond glucose. Such renewables, i.e., polymers, complex substrate mixtures and diluted waste streams, often cannot be metabolized naturally by the producing organisms. This particularly holds for well-known microorganisms from the traditional sugar-based biotechnology, including Escherichia coli, Corynebacterium glutamicum and Saccharomyces cerevisiae which have been engineered successfully to produce a broad range of products from glucose. In order to make full use of their production potential within the bio-refinery value chain, they have to be adapted to various feed-stocks of interest. This review focuses on the strategies to be applied for this purpose which combine rational and evolutive approaches. Hereby, the three industrial platform microorganisms, E. coli, C glutamicum and S. cerevisiae are highlighted due to their particular importance. (C) 2012 Elsevier Ltd. All rights reserved.
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