期刊
SCIENCE IMMUNOLOGY
卷 3, 期 23, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciimmunol.aan0829
关键词
-
类别
资金
- European Community [HEALTH-2010.2.4.5-2 ALLFUN]
- INSERM
- Sorbonne Universite
- Universite Paris Descartes
- Indo-French Center for Promotion of Advanced Research
- La Fondation pour la Recherche Medicale, France [FDM20150633674]
Basophils are a rare granulocyte population that has been associated with allergic and inflammatory responses. It is essential to understand the regulatory mechanisms by which basophils are kept in check, considering the impact of dysregulated basophil function on immune responses under different pathological conditions. Among immunoregulatory cells, CD4(+)CD25(+)FoxP3(+) regulatory T cells (L-regs) are the key players that maintain immune tolerance. The mechanisms by which T-regs regulate and suppress diverse immune cell subsets have been studied extensively, but the impact of T-regs on basophil functions is not well understood. We report that human basophils are refractory to T-regs-mediated suppression and found that T-regs stimulate resting basophils to induce the expression of activation markers including CD69, CD203c, and CD13 and the release of basophil cytokines including IL-13, IL-8, and IL-4. Mechanistically, Tregs could induce human basophil activation via IL-3 and STAT5 activation, whereas cellular contact was dispensable. Inhibition of either IL-3-IL-3 receptor interactions or STAT5 phosphorylation abrogated T-regs-mediated activation of basophils. These results provide evidence of direct positive effects that human T-regs have on basophil activation and reveal a previously unrecognized feature of this cell subset well known for immunosuppressive functions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据