期刊
BIORESOURCE TECHNOLOGY
卷 149, 期 -, 页码 367-374出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biortech.2013.09.098
关键词
Biocatalysis; Continuous-flow condition; Packed bed enzyme microreactor; Propyl caffeate; Transesterification
资金
- China Postdoctoral Science Foundation Funded Projects [2012M510124, 2013T60505]
- Natural Science Foundation of China [21206061]
- Postdoctoral Science Foundation Funded Project of Jiangsu University [1143002085]
- Qing Lan Project of Jiangsu Province
- Graduate Innovation Project of Jiangsu Province [2012JSSPITP1482]
- Start Project for Introduced Talent at Jiangsu University of Science and Technology [35211002]
Propyl caffeate has the highest antioxidant activity among caffeic acid alkyl esters, but its industrial production via enzymatic transesterification in batch reactors is hindered by a long reaction time (24 h). To develop a rapid process for the production of propyl caffeate in high yield, a continuous-flow microreactor composed of a two-piece PDMS in a sandwich-like microchannel structure was designed for the transesterification of methyl caffeate and 1-propanol catalyzed by Novozym 435 in [Bmim][CF3SO3]. The maximum yield (99.5%) in the microreactor was achieved in a short period of time (2.5 h) with a flow rate of 2 mu L/min, which kinetic constant K-m was 16 times lower than that of a batch reactor. The results indicated that the use of a continuous-flow packed bed enzyme microreactor is an efficient method of producing propyl caffeate with an overall yield of 84.0%. (C) 2013 Elsevier Ltd. All rights reserved.
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