期刊
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
卷 10, 期 -, 页码 1-24出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1758835918794630
关键词
cancer; circulating tumor cells; circulating tumor DNA; exosomes; liquid biopsy; targeted therapy
类别
资金
- Associazione Italiana per la Ricerca sul Cancro from the Apulia Region [17536]
Over the last decades, the concept of precision medicine has dramatically renewed the field of medical oncology; the introduction of patient-tailored therapies has significantly improved all measurable outcomes. Liquid biopsy is a revolutionary technique that is opening previously unexpected perspectives. It consists of the detection and isolation of circulating tumor cells, circulating tumor DNA and exosomes, as a source of genomic and proteomic information in patients with cancer. Many technical hurdles have been resolved thanks to newly developed techniques and next-generation sequencing analyses, allowing a broad application of liquid biopsy in a wide range of settings. Initially correlated to prognosis, liquid biopsy data are now being studied for cancer diagnosis, hopefully including screenings, and most importantly for the prediction of response or resistance to given treatments. In particular, the identification of specific mutations in target genes can aid in therapeutic decisions, both in the appropriateness of treatment and in the advanced identification of secondary resistance, aiming to early diagnose disease progression. Still application is far from reality but ongoing research is leading the way to a new era in oncology. This review summarizes the main techniques and applications of liquid biopsy in cancer.
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