期刊
INTERNATIONAL JOURNAL OF EMERGENCY MEDICINE
卷 11, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12245-018-0215-6
关键词
Anticoagulants; Haemorrhage; Non-vitamin K antagonist oral anticoagulants; Dabigatran; Rivaroxaban; Edoxaban; Apixaban; Prothrombin complex concentrates; Anticoagulant reversal
资金
- CSL Behring
BackgroundBleeding complications are a risk associated with all anticoagulants. Currently, the treatment options for the management of direct oral anticoagulant (DOAC)-associated bleeding are limited. Prothrombin complex concentrates (PCCs) have been proposed as a potential therapeutic option, and evidence regarding their use is increasing.ReviewMany studies supporting PCC have used preclinical models and healthy volunteers; however, more recently, observational studies have further improved insight into current DOAC reversal strategies. Multiple clinical practice guidelines now specifically suggest use of PCCs for this indication. Specific reversal agents for Factor Xa inhibitors may become available in the near future, but data on their efficacy are still emerging.ConclusionsUltimately, a multimodal approach may be the optimal strategy to restore haemostasis in patients presenting with DOAC-associated coagulopathy.
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