期刊
MOSCOW UNIVERSITY CHEMISTRY BULLETIN
卷 73, 期 5, 页码 248-250出版社
PLEIADES PUBLISHING INC
DOI: 10.3103/S0027131418050036
关键词
MCF7; MCF7/ADR; breast cancer cell culture; drug resistance; epithelial-mesenchymal transition; vimentin; P-gp; flow cytometry
资金
- Russian Science Foundation [14-15-00362]
Drug-sensitive MCF7 cells and drug-resistant MCF7/ADR cells are shown to differ with regard to the vimentin and P-gp expression levels, which is indicative of the coexistence of two drug resistance mechanisms in MCF7/ADR cells. The mesenchymal phenotype of epithelial cells makes a much greater contribution to the resistance mechanisms than the ABC transporter's overexpression, since the difference in the vimentin expression levels in drug-sensitive and drug-resistant cultures is significantly higher than the difference in the P-gp expression.
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