期刊
BIOLOGICAL RESEARCH
卷 51, 期 -, 页码 -出版社
SOC BIOLGIA CHILE
DOI: 10.1186/s40659-018-0166-7
关键词
Magnetic resonance spectroscopy (MRS); Electroacupuncture; Learning and memory; N-Acetylaspartate (NAA); Glutamate (Glu)
类别
资金
- National Natural Science Foundation of China [81774386]
- Fujian Rehabilitation Technology of Collaborative Innovation Center Support Project [X2012004, X2016001, X2017002]
- Fujian Natural Science Foundation of China [2015J01335]
- Science and technology innovation platform project of Fujian University of Traditional Chinese Medicine [X2015024]
Objective: To explore the precise mechanism of electroacupuncture (EA) to delay cognitive impairment in Alzheimer disease. Methods: N-Acetylaspartate (NAA), glutamate (Glu) and myoinositol (mI) metabolism were measured by magnetic resonance spectroscopy, learning and memory of APP/PS1 mouse was evaluated by the Morris water maze test and the step-down avoidance test, neuron survival number and neuronal structure in the hippocampus were observed by Nissl staining, and BDNF and phosphorylated TrkB detected by Western blot. Results: EA at DU20 acupuncture significantly improve learning and memory in behavioral tests, up-regulate NAA, Glu and mI metabolism, increase the surviving neurons in hippocampus, and promote the expression of BDNF and TrkB in the APP/PS1 transgenic mice. Conclusion: These findings suggested that EA is a potential therapeutic for ameliorate cognitive dysfunction, and it might be due to EA could improve NAA and Glu metabolism by upregulation of BDNF in APP/PS1 mice.
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