期刊
FLEXIBLE AND PRINTED ELECTRONICS
卷 3, 期 3, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/2058-8585/aad433
关键词
electronic biosensing; immunosensing; antigen-antibody interaction; OFET; rGO-FET; biomimetic smell sensing
资金
- European Science Foundation (ESF) [10-EuroBioSAS-FP-005]
- Austrian Science Fund (FWF) [I681-N24]
- Austrian Federal Ministry for Transportation, Innovation and Technology [GZBMVIT-612.166/0001-III/I1/2010]
- FFG within the Comet Program
- government of Lower Austria
- government of Upper Austria
In this short review, we summarize the design and implementation of organic semiconducting materials-based field-effect transistors (OFETs) and the fabrication and use of reduced graphene-oxide field-effect transistors (rGO-FETs) as flexible transducers for electronic biosensing. We demonstrate that these platforms allow for the quantitative, in situ, and in real time monitoring of bio-affinity reactions between analytes from solution to the surface-immobilized receptors. The examples given include the binding of anti-bovine serum albumin (BSA) antibodies to their antigen, BSA, covalently attached to the channel of an OFET, or the reverse mode of operation, i.e., the binding of BSA from solution to the antibodies immobilized on a rGO transistor. Finally, we will discuss a few results obtained with odorant binding proteins used as receptors on a rGO-FET transducer for the realization of a biomimetic smell sensor.
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