期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 407, 期 28, 页码 8585-8604出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-015-9017-3
关键词
Pharmaceuticals; LC-MS-MS; Wastewater; Surface water; Suspended solids; Sediment
资金
- Etiage program (Agence de l'Eau Adour-Garonne)
- Etiage program (Communaute Urbaine de Bordeaux (CUB))
- Etiage program (Lyonnaise des Eaux)
- Aquitaine Region
- European Union (CPER A2E project)
Comprehensive source and fate studies of pharmaceuticals in the environment require analytical methods able to quantify a wide range of molecules over various therapeutic classes, in aqueous and solid matrices. Considering this need, the development of an analytical method to determine 53 pharmaceuticals in aqueous phase and in solid matrices using a combination of microwave-assisted extraction, solid phase extraction, and liquid chromatography coupled with tandem mass spectrometry is reported. Method was successfully validated regarding linearity, repeatability, and overall protocol recovery. Method detection limits (MDLs) do not exceed 1 ng L-1 for 40 molecules in aqueous matrices (6 ng L-1 for the 13 remaining), while subnanogram per gram MDLs were reached for 38 molecules in solid phase (29 ng g(-1) for the 15 remaining). Losses due to preparative steps were assessed for the 32 analytes associated to their labeled homologue, revealing an average loss of 40 % during reconcentration, the most altering step. Presence of analytes in wastewater treatment plant (WWTP) effluent aqueous phase and suspended solids (SS) as well as in river water, SS, and sediments was then investigated on a periurban river located in the suburbs of Bordeaux, France, revealing a major contribution of WWTP effluent to the river contamination. Sorption on river SS exceeded 5 % of total concentration for amitriptyline, fluoxetine, imipramine, ritonavir, sildenafil, and propranolol and appeared to be submitted to a seasonal influence. Sediment contamination was lower than the one of SS, organic carbon content, and sediment fine element proportion was accountable for the highest measured concentrations.
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