期刊
BIORESOURCE TECHNOLOGY
卷 101, 期 21, 页码 8383-8388出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biortech.2010.06.052
关键词
Actinoplanes sp HBDN08; Antifungal activity; 5-Hydroxyl-5-methy1-2-hexenoic acid
资金
- The National Key Project for Basic Research [2010CB1126102]
- The National Natural Science Foundation of China [30571234, 30771427]
- The National Key Technology RD Program [2006BAD31B]
A bioactivity-guided approach was employed to isolate and determine the chemical identity of bioactive constituents with antifungal activity from Actinoplanes sp. HBDN08. The structure of the antifungal metabolite was elucidated as 5-hydroxyl-5-methyl-2-hexenoic acid on the basis of spectral analysis. This compound showed strong in vitro antifungal activity against Botrytis cinerea, Cladosporium cucumerinum and Corynespora cassiicola, with an IC50 of 32.45, 27.17, and 30.66 mg/L, respectively; however, it only moderately inhibited hyphal growth of Rhizoctonia solani with an IC50 of 61.64 mg/L. The in vivo antifungal activity under greenhouse conditions demonstrated that 5-hydroxyl-5-methyl-2-hexenoic acid could effectively control the diseases caused by B. cinerea, C. cucumerinum and C. cassiicola with 71.42%, 78.63% and 65.13% control values at 350 mg/L, respectively. This strong antifungal activity suggests that 5-hydroxyl-5-methyl-2-hexenoic acid might be a promising candidate for new antifungal agents. (C) 2010 Elsevier Ltd. All rights reserved.
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