期刊
ACTA CHROMATOGRAPHICA
卷 30, 期 1, 页码 62-65出版社
AKADEMIAI KIADO RT
DOI: 10.1556/1326.2017.00242
关键词
Acyclovir; Alaptide; Permeation; Skin; Franz diffusion cell; HPLC determination
资金
- IGA VFU [302/2015/FaF]
- Technology Agency of the Czech Republic [TA04010065]
- Institute of Analytical Chemistry of the CAS, v.v.i. [RVO:68081715]
The investigation deals with the affection of the permeation of acyclovir through full-thickness pig ear skin using a Franz diffusion cell from the donor vehicles of phosphate buffer (pH 7.4) and propylene glycol-water (1: 1) using synthesised (S)-8-methyl-6,9-diazaspiro[4.5] decane-7,10-dione, alaptide as a transdermal permeation enhancer. Alaptide was applied in ratio 1:10 (w/w) relative to the amount of acyclovir. At the first hour after application, the permeated amount of acyclovir from propylene glycol-water system, simulating semisolid dosage forms, was ca. four-fold higher than from the formulation without alaptide. Despite that the enhancement ratio of alaptide in a steady state was 1.7, the pseudo-enhancement ratio of alaptide in the time range of first to third hour was 2.3. Both enhancement ratios indicate that alaptide modifies skin structure, while the short-term application of the alaptide formulation seems to be more advantageous.
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