期刊
CLINICAL & TRANSLATIONAL IMMUNOLOGY
卷 7, 期 6, 页码 -出版社
WILEY
DOI: 10.1002/cti2.1019
关键词
cystic fibrosis; endoplasmic reticulum stress; inflammation; lung disease; oxidative stress; protein misfolding; respiratory epithelium
类别
资金
- National Health and Medical Research Council Principal Research Fellowship [APP1059726]
Oxidative stress and endoplasmic reticulum (ER) stress are related states that can occur in cells as part of normal physiology but occur frequently in diseases involving inflammation. In this article, we review recent findings relating to the role of oxidative and ER stress in the pathophysiology of acute and chronic nonmalignant diseases of the lung, including infections, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. We also explore the potential of drugs targeting oxidative and ER stress pathways to alleviate disease.
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