期刊
PHOTOACOUSTICS
卷 9, 期 -, 页码 10-20出版社
ELSEVIER GMBH
DOI: 10.1016/j.pacs.2017.11.001
关键词
Portable photoacoustic imaging; LED; Optoacoustic imaging; Molecular imaging
类别
资金
- NIH [HL117048, HL137187, S10 OD021821]
- American Cancer Society Institutional Research through the Moores Cancer Center, University of California, San Diego [14-250-42]
- UC San Diego via the Frontiers of Innovation Scholars Program (FISP)
- NATIONAL CANCER INSTITUTE [T32CA153915] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R00HL117048, K99HL117048, DP2HL137187] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [S10OD021821] Funding Source: NIH RePORTER
Photoacoustic imaging (PAI) is a non-invasive, high-resolution hybrid imaging modality that combines optical excitation and ultrasound detection. PAI can image endogenous chromophores (melanin, hemoglobin, etc.) and exogenous contrast agents in different medical applications. However, most current equipment uses sophisticated and complicated OPO lasers with tuning and stability features inconsistent with broad clinical deployment. As the number of applications of PAI in medicine increases, there is an urgent need to make the imaging equipment more compact, portable, and affordable. Here, portable light emitting diode - based photoacoustic imaging (PLED-PAI) was introduced and characterized in terms of system specifications, light source characterizations, photoacoustic spatial/temporal resolution, and penetration. The system uses two LED arrays attached to the sides of a conventional ultrasound transducer. The LED pulse repetition rate is tunable between 1 K Hz, 2 K Hz, 3 K Hz, and 4 K Hz. The axial resolution was 0.268 mm, and the lateral resolution was between 0.55 and 0.59 mm. The system could detect optical absorber (pencil lead) at a depth of 3.2 cm and the detection limits of indocyanine green (ICG) and methylene blue (MB) were 9 mu M and 0.78 mM. In vivo imaging of labeled human mesenchymal stem cells was achieved to confirm compatibility with small animal imaging. The characterization we report here may have value to other groups evaluating commercially available photoacoustic imaging equipment. (C) 2017 The Authors. Published by Elsevier GmbH.
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