期刊
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 53, 期 1, 页码 64-82出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10409238.2017.1394265
关键词
PARP; ADP-ribosyl transferase; ADP-ribosylation; reversible protein modification; macrodomain; PARG; ARH3; DNA damage
资金
- Wellcome Trust [101794]
- Cancer Research UK [C35050/A22284]
- Deutsche Forschungsgemeinschaft (Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases) [EXC 229]
- European Union's Horizon 2020 research and innovation program [Marie Sklodowska-Curie] [657501]
- Croatian Science Foundation [IP-2016-06-4242]
- Cancer Research UK [22284] Funding Source: researchfish
Proper and timely regulation of cellular processes is fundamental to the overall health and viability of organisms across all kingdoms of life. Thus, organisms have evolved multiple highly dynamic and complex biochemical signaling cascades in order to adapt and survive diverse challenges. One such method of conferring rapid adaptation is the addition or removal of reversible modifications of different chemical groups onto macromolecules which in turn induce the appropriate downstream outcome. ADP-ribosylation, the addition of ADP-ribose (ADPr) groups, represents one of these highly conserved signaling chemicals. Herein we outline the writers, erasers and readers of ADP-ribosylation and dip into the multitude of cellular processes they have been implicated in. We also review what we currently know on how specificity of activity is ensured for this important modification.
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