期刊
CANNABIS AND CANNABINOID RESEARCH
卷 3, 期 1, 页码 166-170出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/can.2018.0021
关键词
anandamide; hedonic hotspot; nucleus accumbens; opioid; pleasure; taste reactivity
资金
- NIDA NIH HHS [R01 DA015188, R00 DA035251] Funding Source: Medline
- NIMH NIH HHS [R01 MH063649] Funding Source: Medline
Introduction: Stimulating either endogenous cannabinoids or opioids within a restricted dorsomedial hedonic hotspot in nucleus accumbens (NAc) shell enhances hedonic impact, or liking reactions to sweet tastes. In this study, we probed within this hotspot the relationship between endocannabinoid and opioid signals in hedonic enhancement. Materials and Methods: Specifically, we asked whether enhancement of sucrose liking by intra-NAc microinjections of the endocannabinoid anandamide requires concurrent endogenous opioid signaling. Results: Co-administration of the opioid antagonist naloxone in the same NAc microinjections with anandamide prevented the endocannabinoid from enhancing orofacial liking reactions to sucrose. Since intra-NAc hotspot naloxone injection alone failed to affect hedonics, reversal of anandamide-induced liking by opioid blockade reveals an interdependence of opioid and cannabinoid signaling in enhancing taste hedonic impact. Conclusions: These results elaborate our understanding of the mechanisms of hedonic processing of food rewards, and may also carry implications more generally for how opioid and cannabinoid drugs interact to generate natural pleasures, or drug-induced euphoria.
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