期刊
PATIENT-RELATED OUTCOME MEASURES
卷 9, 期 -, 页码 353-367出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/PROM.S156279
关键词
patient-reported outcomes; quality of life; trial conduct; research practices; clinical trials as topic
资金
- NHMRC
- NIHR Birmingham Biomedical Research Centre at the University Hospitals Birmingham NHS Foundation Trust
- NIHR Surgical Reconstruction and Microbiology Research Centre at the University Hospitals Birmingham NHS Foundation Trust
- University of Birmingham
- Australian Government of Cancer Australia
Patient-reported outcomes (PROs) can be included in clinical trials as primary or secondary endpoints and are increasingly recognized by regulators, clinicians, and patients as valuable tools to collect patient-centered data. PROs provide unique information on the impact of a medical condition and its treatment from the patient's perspective; therefore, PROs can be included in clinical trials to ensure the impact of a trial intervention is comprehensively assessed. This review first discusses examples of how PRO endpoints have added value to clinical trial interpretation. Second, it describes the problems with current practices in designing, implementing, and reporting PRO studies, and how these problems may be addressed by complying with guidance for protocol development, selecting appropriate PRO measures to match clinically motivated PRO hypotheses, minimizing the rates of avoidable missing PRO data, analyzing and interpreting PRO data, and transparently reporting PRO findings.
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