期刊
STUDIES IN MYCOLOGY
卷 -, 期 91, 页码 61-78出版社
CENTRAALBUREAU SCHIMMELCULTURE
DOI: 10.1016/j.simyco.2018.10.001
关键词
Aspergillus; Genomic diversity; Gold standard genome; Sugar catabolism
类别
资金
- SURF Cooperative Grant [170088]
- Genome Quebec
- Dutch Technology Foundation STW, Applied Science division of NWO
- Technology Program of the Dutch Ministry of Economic Affairs [016.130.609]
- Genome Canada
The fungal kingdom is too large to be discovered exclusively by classical genetics. The access to omics data opens a new opportunity to study the diversity within the fungal kingdom and how adaptation to new environments shapes fungal metabolism. Genomes are the foundation of modern science but their quality is crucial when analysing omics data. In this study, we demonstrate how one gold-standard genome can improve functional prediction across closely related species to be able to identify key enzymes, reactions and pathways with the focus on primary carbon metabolism. Based on this approach we identified alternative genes encoding various steps of the different sugar catabolic pathways, and as such provided leads for functional studies into this topic. We also revealed significant diversity with respect to genome content, although this did not always correlate to the ability of the species to use the corresponding sugar as a carbon source.
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