期刊
BIOPOLYMERS
卷 95, 期 8, 页码 543-549出版社
WILEY-BLACKWELL
DOI: 10.1002/bip.21604
关键词
RNA folding; small angle X-ray scattering; ion-nucleic acid interactions
Small angle X-ray scattering provides low resolution structural information about macromolecules in solution. When coupled with rapid mixing methods, SAXS reports time-dependent conformational changes of RNA induced by the addition of Mg(2+) to trigger folding. Thus time-resolved SAXS provides unique information about the global or overall structures of transient intermediates populated during folding. Notably, SAXS provides information about the earliest folding events, which can evade detection by other methods. (C) 2011 Wiley Periodicals, Inc. Biopolymers 95: 543-549, 2011.
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