期刊
BIOPOLYMERS
卷 95, 期 11, 页码 733-745出版社
WILEY
DOI: 10.1002/bip.21646
关键词
shear flow; protein; unfolding; aggregation; amyloid fibril; physiology; bioprocessing
Protein molecules are subjected to potentially denaturing fluid shear forces during processing and in circulation in the body. These complex molecules, involved in numerous biological functions and reactions, can be significantly impaired by molecular damage. There have been many studies on the effects of hydrodynamic shear forces on protein structure and function. These studies are reviewed and the implications to bioprocessing and pathophysiology of certain diseases are discussed. (C) 2011 Wiley Periodicals, Inc. Biopolymers 95: 733-745, 2011.
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