期刊
BIOPOLYMERS
卷 94, 期 5, 页码 602-610出版社
WILEY
DOI: 10.1002/bip.21466
关键词
bioreactor; cyclic peptides kalata B1; Oldenlandia affinis; suspension culture
Cyclotides are disulfide-rich miniproteins with a circular backbone and a knotted arrangement of disulfide bonds. Because these plant-derived peptides are resistant to degradation and exhibit a diverse range of bioactivities, they have become important agronomic and industrial objectives. They belong to a group of compounds with low market volume and high price that are poorly processed by microorganisms, are too complex for economic chemical synthesis, and thus are valuable candidates for the synthesis in plant cell bioprocesses. This review highlights current research aimed at production routes of cyclotides in Oldenlandia affinis plantlets and cell cultures, and summarizes recent advances in bioprocessing aspects, with particular emphasis on the development of suitable bioreactor configurations for plant cell culture-based processes, the optimization of culture environments as a powerful means to improve yields, bioreactor operational modes, and trends in protein recovery. (c) 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 602-610, 2010.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据