期刊
BIOPHYSICAL JOURNAL
卷 107, 期 3, 页码 548-554出版社
CELL PRESS
DOI: 10.1016/j.bpj.2014.06.036
关键词
-
类别
资金
- National Science Foundation [DMS-1068869]
- National Science Foundation Center for Theoretical Biological Physics [NSF PHY-1308264]
- Cancer Prevention & Research Institute of Texas Scholar program
Cells migrate collectively during development, wound healing, and cancer metastasis. Recently, a method has been developed to recover intercellular stress in monolayers from measured traction forces upon the substrate. To calculate stress maps in two dimensions, the cell sheet was assumed to behave like an elastic material, and it remains unclear to what extent this assumption is valid. In this study, we simulate our recently developed model for collective cell migration, and compute intercellular stress maps using the method employed in the experiments. We also compute these maps using a method that does not depend on the traction forces or material properties. The two independently obtained stress patterns agree well for the parameters we have probed and provide a verification of the validity of the experimental method.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据